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화학과 특별 세미나가 다음 주 목요일(8월 10일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Recent Progress in Chiral Phosphoric Acid Catalysis연 사 : Prof. Takahiko Akiyama(Gakushuin University)일 시 : 2023년 8월 10일(목) 오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================
화학과 특별 세미나가 내일(8월 1일) 오전 11시에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Defective chemistry through the eyes of nuclear spins: unlocking the detective potential of NMR연 사 : 이정재 박사(School of Earth and Environmental Sciences, 서울대학교)일 시 : 2023년 8월 1일(화) 오전 11시장 소 : 화학관 2층 330226호실================================================================================Defective chemistry through the eyes of nuclear spins: unlocking the detective potential of NMR Jeongjae Lee School of Earth and Environmental Sciences Seoul National UniversityIn mathematics and physics, many chemical structures can often be elegantly described in terms of their periodicity and/or symmetry. In chemistry and materials science, however, the interesting properties of many solid materials are determined by their non-periodic, i.e., defective, nature. NMR spectroscopy, which relies on the interaction of nuclear spins with their immediate chemical environments, provides an excellent probe into the structure and dynamics of these defects, which are often challenging to investigate by other structural techniques.In this talk, I will highlight some of our recent investigations in materials chemistry involving solid-state NMR spectroscopy as the primary tool. Topics covered include: structure and electronic doping of 2-dimensional metal-halide perovskites[1,2], surface functionalization and interface phenomena in metal-halide perovskites[3,4], and ion dynamics in Mg-ion battery cathode material Mg3Bi2[5,6].[1] “Bulk Incorporation of Molecular Dopants into Ruddlesden–Popper Organic Metal–Halide Perovskites for Charge Transfer Doping”, Adv. Funct. Mater. In press.[2] “Layer-by-Layer Structural Identification of 2D Ruddlesden–Popper Hybrid Lead Iodide Perovskites by Solid-State NMR Spectroscopy”, Chem. Mater. 33, 370 (2021).[3] “Ligand-Engineered Bandgap Stability in Mixed-Halide Perovskite LEDs”, Nature 591, 72 (2021).[4] “Mechanochemistry-driven engineering of 0D/3D heterostructure for designing highly luminescent Cs–Pb–Br perovskites”, Nat. Commun. 13, 4263 (2022).[5] “An Ab Initio Investigation on the Electronic Structure, Defect Energetics, and Magnesium Kinetics in Mg3Bi2”, J. Mater. Chem. A 6, 16983 (2018).[6] “Insights into the Electrochemical Performances of Bi Anodes for Mg Ion Batteries Using 25Mg Solid State NMR Spectroscopy”, Chem. Commun 53, 743 (2017).
화학과 특별 세미나가 다음주 수요일(6월 14일) 오전 10시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Access Molecular Complexity by Breaking Symmetry of Dicarbonyl Compounds연 사 : Prof. Zhongxing Huang(University of Hong Kong)일 시 : 2023년 6월 14일(수)오전 10시 30분장 소 : 화학관 2층 330226호실================================================================================Access Molecular Complexity by Breaking Symmetry of Dicarbonyl CompoundsZhongxing HuangUniversity of Hong Konghuangzx@hku.hk 1,3-Dicarbonyl compounds represent a prominent family of structures that are easily available and can provide rapid access to complex molecules. When doubly substituted, these compounds can be rapidly converted to valuable tetrasubstituted stereocenters via asymmetric transformations. Here, we report a prolinol- or pipecolinol-derived tetradentate ligand scaffold that can house two zinc centers or a single magnesium atom to desymmetrize malonic esters and 1,3-diketones. The reductive desymmetrization of disubstituted malonic ester via hydrosilylation has enabled the stereoselective synthesis of various enantioenriched building blocks, including quaternary stereocenters, tertiary alkyl halides, α-tertiary amines, and tertiary alcohols. Consequently, novel and expeditious approaches to bioactive natural metabolites, such as 2-dechlorohalomon, conagenin, and yezo’otogirins, were devised. Meanwhile, the magnesium-catalyzed desymmetric cyanosilylation of acyclic 1,3-diketones using the same ligand scaffolds afforded two vicinal tetrasubstituted carbons. The polyfunctionalized nature of the chiral cyanohydrin products can be used to access molecules of higher complexity, particularly those with consecutive stereocenters.References:(1) Xu, Pengwei.; Huang, Z.*, Nat. Chem. 2021, 13, 634.(2) Zheng, Y.; Zhang, S.; Low, K.-H.; Zi, W.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 1951-1961.(3) Xu, Pengwei.; Liu, S.; Huang, Z.*, J. Am. Chem. Soc. 2022, 144, 6918-6927.(4) Xu, Pan.; Shen, C.; Xu, A.; Low, K.-H.; Huang, Z.*, Angew. Chem. Int. Ed. 2022, 61, e202208443.(5) Liu, Haichao; Lau, H. M.; Xu, P.; Chan, T. H.; Huang, Z.*, Nat. Commun. 2022, 13, 4759.
화학과 특별 세미나가 다음주 금요일(6월 9일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : 제약산업에서 공정 개발의 이해(Pharmaceutical Process R&D)연 사 : 오상호 상무님(유한양행 중앙연구소)일 시 : 2023년 6월 9일(금)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================
화학과 세미나가 다음주 목요일(6월 8일) 오후 4시 30분에 개최됩니다.2023-1학기 마지막 정규세미나로 많은 관심과 참여 부탁드립니다.===============================================================================제 목 : Opto-electronic Sensor via N/MEMS for monitoring nano/biomaterials연 사 : 유용상 교수님(고려대학교)일 시 : 2023년 6월 8일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Opto-electronic Sensor via N/MEMS for monitoring nano/biomaterials Yong-Sang Ryu School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korearongxiang82@korea.ac.kr Detection and monitoring of nano/biomaterials are indispensable for investigating the biological and chemical activities in the human life. In this seminar, we introduced a variety of detection approaches, in particularly via NEMS/MEMS approaches, dealing with nano/biomaterials such as ultrafine dust, microplastic, and virus, extracellular vesicle etc. Moreover, optical approaches is also introduced using metal-insulator-metal etalon structures using Fabry-Perot phenomenon.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 다음주 목요일(6월 1일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : 실리콘-기반 혁신 의료소재 개발 및 이의 임상학적 응용연 사 : 김도경 교수님(경희대학교 의과대학)일 시 : 2023년 6월 1일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================실리콘-기반 혁신 의료소재 개발 및 이의 임상학적 응용김도경*경희대학교 의과대학 조교수, 서울캠퍼스실리콘 소재는 다양한 의료분야에 사용되고 있다. 실리콘은 생체적합성이 높고 비교적 간단한 기능화 과정을 통해 그 용도가 손쉽게 조절 가능하다는 장점을 갖는다. 본 강연은 2개의 주제로 구성되어 있다.주제1: 본 주제는 알츠하이머병의 주요 발병원인 중 하나인 아밀로이드-베타 플라크를 풀어줌으로서 알츠하이머병의 궁극적 치료가 가능한 신약 물질 도출에 관한 내용과, 이 물질을 담지하여 알츠하이머 뇌로 특이적으로 약물을 전달하는 “다공성실리콘 나노입자” 플랫폼에 관한 내용이다.주제 2: 본 주제는 실리콘-고분자를 기반으로 하여 피부를 통한 약물전달 시스템인 “실리콘-기반 경피 전달” 플랫폼에 관한 내용이다. 본 기술은 다양한 임상학적 시험이 적용되었고, 최근 제약회사에 기술이전 되었다. 본 주제에서는 소재의 개발로부터 임상에 적용되기까지의 과정이 소개된다.연자 연락처: 김도경 교수, dkim@khu.ac.kr 강연 관련 주요 논문1. D. Kim*, “Potential Alzheimer’s disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles”, Bioactive Materials, 2023, 24, 497.2. D. Kim*, “A transformable and biocompatible polymer series using ring-opening polymerization of cyclic silane for more effective transdermal drug delivery”, Chemical Engineering Journal, 2022, 440, 135989.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 다음주 목요일(5월 25일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Functional Nanomaterials for Healthcare Applications연 사 : 이준석 교수님(한양대학교 화학과)일 시 : 2023년 5월 25일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Functional Nanomaterials for Healthcare ApplicationsJoonseok Lee Recently, the area of nanostructure research is gradually moving toward the directions of the rational design of functional nanostructures for healthcare applications. In this talk, I will briefly overview recent progress and a collection of advances, particularly on the synthesis, characterization, and utilization of lanthanide-doped nanomaterials and 3D-networked porous nanostructures.Part 1) Near-infrared emitting nanoparticlesUpconversion nanoparticles (UCNPs) are promising materials for biological applications based on luminescence resonance energy transfer (LRET). In contrast to classical RET donors such as quantum dots, gold nanoparticles, UCNPs can emit near-infrared (NIR) upon the NIR irradiation, which provides enhanced signal-to-noise due to strong penetration and low autofluorescence in the NIR region known as the diagnostic window. Here we report the first efficient NIR-to-NIR signal-based LRET system for the detection of progesterone, chosen as a proof-of-concept target, via homogeneous competitive immunoassay. To enhance the efficiency of LRET, we constructed inert-core/active-shell/inert-ultrathin shell UCNPs as an LRET donor and a compact progesterone/horseradish peroxidase/IRdyeQC-1 (P-HRP-dyes) complex as an LRET acceptor. The designed donor and acceptor showed significantly improved LRET efficiencies (95% and 85% for donor and acceptor, respectively) compared with conventional donor and acceptor (70% and 50%, respectively). The efficient NIR-to-NIR signal-based LRET system has potential as a simple probe for homogeneous competitive immunoassay, with the ability to rapidly detect biomarkers.Part 2) 3D-networked highly porous nanostructuresAbnormal accumulation of β-amyloid (Aβ) peptide aggregates in brain is a major hallmark of Alzheimer's disease (AD). Aβ aggregates interfere with neuronal communications, ultimately causing neuronal damage and brain atrophy. Much effort has been made to develop AD treatments that suppress Aβ aggregate formation, thereby attenuating Aβ-induced neurotoxicity. Here, we report the design of Aβ nanodepletors consisting of ultra-large mesoporous nanostructures and anti-Aβ single-chain variable fragments (scFvs), with the goal of targeting and eliminating aggregative Aβ monomers. The Aβ nanodepletors impart a notable decline in Aβ aggregate formation, resulting in significant mitigation of Aβ-induced neurotoxicity in vitro. Furthermore, stereotaxical injections of Aβ nanodepletors into the brain of an AD mouse model system successfully suppress Aβ plaque formation in vivo up to ~30%, suggesting that Aβ nanodepletors can serve as a promising anti-amylodoisis material. * 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 다음주 월요일(5월 22일) 오후 4시 30분에 개최됩니다.장소는 화학관 1층 330126호실입니다.많은 참여 부탁드립니다.===============================================================================제 목 : Single photon interferometry and wave-particle duality연 사 : 조민행 교수님(고려대학교)일 시 : 2023년 5월 22일(월)오후 4시 30분장 소 : 화학관 1층 330126호실================================================================================ Single photon interferometry and wave-particle dualityMinhaeng Cho1,21Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science (IBS), Seoul 02841, Republic of Korea2Dept. of Chemistry, Korea University, Seoul 02841, Republic of KoreaWave interferences are a common occurrence in nature and have been utilized in various interferometric processes in the time, frequency, and spatial domains. These processes have facilitated the development of remote-detection quantum spectroscopy with undetected photons, nonlinear optical or chiroptical spectroscopy, and interferometric Rayleigh and Raman scattering microscopy. Moreover, coherent multidimensional spectroscopy has proven to be useful in studying the molecular structure, anharmonic potential energy surface, and intermolecular interactions in condensed phases. In this lecture, I discuss the relationship between single-photon interferometry, quantitative wave-particle duality, spectroscopic dephasing, and quantum decoherence. By utilizing two entangled nonlinear bi-photon sources, we were able to prepare a quantum superposition of path-bin single-photon states with experimental control over the degree of quantum entanglement between quantons and detectors/environments. Measuring the interference of single photons allowed us to establish a quantitative complementarity relation between the wave and particle aspects of quantons. Furthermore, we demonstrated the experimental feasibility of remote-detection quantum spectroscopy with pairs of entangled photons by performing spectroscopy with undetected photons.
화학과 세미나가 다음주 목요일(5월 18일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Chimeric T Cells and Macrophages: Cell Engineering to Expand Their Therapeutic Potentials연 사 : 박희호 교수님(한양대학교 생명공학과)일 시 : 2023년 5월 18일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================ Chimeric T Cells and Macrophages:Cell Engineering to Expand Their Therapeutic Potentials Hee Ho Park 1,*1 Department of Bioengineering, Hanyang University,Seoul 04763, Republic of Koreaparkhh@hanyang.ac.kr Chimeric antigen receptor-T (CAR-T) cell immunotherapy has shown impressive clinical outcomes for hematologic malignancies. However, its broader applications are challenged due to its complex ex vivo cell-manufacturing procedures and low therapeutic efficacy against solid tumors. The limited therapeutic effects are partially due to limited CAR-T cell infiltration to solid tumors and inactivation of CAR-T cells by the immunosuppressive tumor microenvironment. Here, a facile approach is presented to in vivo program macrophages, which can intrinsically penetrate solid tumors, into CAR-M1 macrophages displaying enhanced cancer-directed phagocytosis and antitumor activity. In vivo injected nanocomplexes of macrophage-targeting nanocarriers and CAR-interferon-γ-encoding plasmid DNA induce CAR-M1 macrophages that are capable of CAR-mediated cancer phagocytosis, antitumor immunomodulation, and inhibition of solid tumor growth. Together, this study describes an off-the-shelf CAR-macrophage therapy that is effective for solid tumors and avoids the complex and costly processes of ex vivo CAR-cell manufacturing. Severe infectious diseases, such as coronavirus disease 2019 (COVID-19), can induce hypercytokinemia and multiple organ failure. In spite of the growing demand for peptide therapeutics against infectious diseases, current small molecule-based strategies still require frequent administration due to limited half-life and enzymatic digestion in blood. To overcome this challenge, a strategy to continuously express multi-level therapeutic peptide drugs on the surface of immune cells, is established. Here, chimeric T cells stably expressing therapeutic peptides are presented for treatment of severe infectious diseases. Using lentiviral system, T cells are engineered to express multi-level therapeutic peptides with matrix metallopeptidases- (MMP-) and tumor necrosis factor alpha converting enzyme- (TACE-) responsive cleavage sites on the surface. The enzymatic cleavage releases �-carboxyglutamic acid of protein C (PC-Gla) domain and thrombin receptor agonist peptide (TRAP), which activate endothelial protein C receptor (EPCR) and protease-activated receptor-1 (PAR-1), respectively. These chimeric T cells prevent vascular damage in tissue -engineered blood vessel and suppress hypercytokinemia and lung tissue damages in vivo, demonstrating promise for use of engineered T cells against sepsis and other infectious-related diseases.* 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
화학과 세미나가 다음주 목요일(5월 11일) 오후 4시 30분에 개최됩니다.많은 참여 부탁드립니다.===============================================================================제 목 : Single-Electron Oxidation-Induced Chemical Transformations: Carbon–Carbon Bond Formation and Selective Oxaziridine Rearrangement연 사 : 우상국 교수님(울산대학교)일 시 : 2023년 5월 11일(목)오후 4시 30분장 소 : 화학관 2층 330226호실================================================================================Single-Electron Oxidation-Induced Chemical Transformations: Carbon–Carbon Bond Formation and Selective Oxaziridine Rearrangement Sang Kook WooDepartment of Chemistry, University of Ulsan, 93 Daehak-Ro, Nam-Gu, Ulsan 44610, KoreaEmail: woosk@ulsan.ac.kr Visible-light photoredox catalysis is an important research area in the field of green and sustainable organic synthesis. One of the main mechanisms involved in photoredox catalysis is single-electron transfer (SET), which has been extensively investigated in our group for the development of greener carbon–carbon bond forming reactions1 and oxaziridine rearrangement.2 In this presentation, I will describe our results on the development and application of neutral silicon radical precursors for the generation of alkyl radicals via SET and the selective rearrangement of oxaziridines into nitrones or amides. Herein, the recent our works will be discussed in detail.References(1) (a) Gontala, A.; Huh, H.; Woo, S. K. Org. Lett. 2023, 25, 21; (b) Nam, S. B.; Khatun, N.; Kang, Y. W.; Park, B. Y.; Woo, S. K. Chem. Commun. 2020, 56, 2873; (c) Khatun, N.; Kim, M. J.; Woo, S. K. Org. Lett. 2018, 20, 6239(2) (a) Park, J.; Park, S.; Jang, G. S.; Kim, R. H.; Jung, J.; Woo, S. K. Chem. Commun. 2021, 57, 9995; (b) Jang, G. S.; Lee, J.; Seo, J.; Woo, S. K. Org. Lett. 2017, 19, 6448 * 졸업논문 교과목 수강자 세미나 필수 참석 안내석사, 석박통합, 박사과정이 수강하는 <졸업논문연구학점 1~6>수강자는 학과에서 개최하는 목요일 정규세미나에 반드시 참석해야함.관련공지(skku.edu)https://skb.skku.edu/chem/News/notice.do?mode=view&articleNo=146936&article.offset=10&articleLimit=10)
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