============================================================ 제 목 : Development of Metal-Catalyzed Direct C-H Amination Reactions 연 사 : 장석복 교수(KAIST) 일 시 : 2016년 12월 1일(목) 오후 4시 15분 장 소 : 화학관 첨단강의실(330118호) ----------------------------------------------------------- Development of Metal-Catalyzed Direct C-H Amination Reactions Sukbok Chang Institute for Basic Science (IBS), Daejeon 305-701, Korea Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 305-701, South Korea E-mail: email@example.com The mechanism of the Ir(III) and Rh(III)-mediated C–N coupling reaction, which is the key step of catalytic C-H amidation, was investigated in an integrated experimental and computational study. Novel amidating agents containing a 1,4,2-dioxazole moiety allowed for designing a stoichiometric version of the catalytic C–N coupling reaction and giving access to reaction intermediates that reveal details about each step of the reaction. Both DFT and kinetic studies strongly point to a mechanism where the M(III) complex engages the amidating agent via oxidative coupling to form a M(V)-imido intermediate, which then undergoes migratory insertion to afford the final C–N coupled product. For the first time, the stoichiometric versions of the Ir and Rh-mediated amidation reaction were compared systematically to each other. Iridium reacts much faster than rhodium (~ 1100 times at 6.7 oC) with the oxidative coupling being so fast that the activation of the initial Ir(III)-complex becomes rate-limiting. In the case of Rh, the Rh-imido formation step is rate-limiting. These qualitative difference stems from a unique bonding feature of the dioxazole moiety and the relativistic contraction of the Ir(V), which affords much more favorable energetics for the reaction. For the first time, a full molecular orbital analysis is presented to rationalize and explain the electronic features that govern this behavior.  S. H. Cho, J. Kim, J. Kwak, Sukbok Chang, Chem. Soc. Rev.2011, 40, 5068-5083  K. Shin, H. Kim, S. Chang, Acc. Chem. Res. 2015, 48, 1040-1052 Y. Park, K. T. Park, J. G. Kim, S. Chang, J. Am. Chem. Soc. 2015, 137, 4534-4542  W. Xie, J. H. Yoon, S. Chang, J. Am. Chem. Soc. 2016, 138, 12605-12614  Y. Park, J. Heo, M.-H. Baik, S. Chang, J. Am. Chem. Soc. 2016, 13
============================================================== 제 목 : 화학작용제 지속도 연구 연 사 : 임종선 부이사관(국군화학방어연구소) 일 시 : 2016년 11월 24일(목) 오후 3시 장 소 : 화학관 2층 세미나실 (330226호실) ============================================================== 화학작용제 지속도 연구 소형풍동장치를 이용하여 화학작용제의 증발 및 소멸특성의 연구를 통해 야전환경 조건 하 화학작용제의 지속도와 관련 데이터를 축적하고자 본 연구를 수행하였다. 실험에 사용한 화학작용제는 HD와 GD이며, 지표물질로는 비다공성 표면으로 유리, 다공성 표면으로 콘크리트 및 나지표면을 이용하여 실험을 진행하였다. 실험에 적용한 환경조건은 온도, 풍속, 오염량의 세가지 변수이며, 온도는 17℃ ~ 45℃, 풍속은 0.8km/h ~ 13km/h, 오염량은 1g/㎡ ~ 10g/㎡의 범위에서 실시하였다. 실험을 통해 획득한 데이터는 美 ECBC의 실험데이터와 비교하기 위해 ECBC에서 데이터를 처리한 방식대로 데이터를 처리해 비교를 실시하였다. 획득한 ECBC 데이터는 HD와 VX 데이터이다. 미국의 데이터와 비교하기 위해 작용제별 증발속도를 산출해 ECBC에서 제시한 증발속도 계산식을 이용하여 계산된 증발속도 값 및 실제 실험을 통해서 획득된 미국의 증발속도 데이터와 비교하였다. 또한, HD의 STEL(short-term exposure limit), VX의 IDLH(immediately dangerous to life or health) 농도에 해당하는 농도인 0.003mg/㎥에 도달될 때까지의 시간을 측정해 ECBC의 계산식에 의한 지속시간과 실제 데이터를 통해 산출한 지속시간도 같이 비교해 데이터의 신뢰성을 확인하였다. 지속도 데이터와 증기농도 및 흡입량을 기준으로한 위험기준을 토대로 지속시간 기준별 위험수준을 확인했고, 잔류량 분석을 통해 잔류위험을 확인하였다. 분석결과 화학작용제의 증기량이 미미한 시점에서도 잔류위험이 존재하는 것으로 확인되었다.
제 목 : Postsynthetic transmetalation of metal-organic frameworks
연 사 : 나명수 교수(UNIST)
일 시 : 2016년 11월 17일(목) 오후 4시 15분 장 소 : 화학관 첨단강의실(330118호)
Postsynthetic transmetalation of metal-organic frameworks
Myoung Soo Lah
Department of Chemistry, Ulsan National Institute of Science & Technology (UNIST)
50 Unist-gil, Ulju-gun, Ulsan, Korea 44919
Fax: +82-(52)-217-2019 E-mail address: firstname.lastname@example.org
The replacements of framework metal ions and ligands were investigated in metal–organic frameworks (MOFs). The transmetalated MOFs could be obtained by soaking an MOF in the solution of a new replacing metal ion. By simply controlling the soaking time, not only fully transmetalated isostructural framework structure but also selectively transmetalated core-shell bimetallic structure could be prepared. The ligand exchanged MOFs could also be obtained via soaking an MOF in the solution of a new replacing ligand. By controlling the concentration of the replacing ligand, not only an entropically favorable MOF with completely exchanged ligand but also enthalpically favorable MOF with selectively exchanged ligand in the alternating layers could be obtained. While there is no significant structural rearrangement of the framework during the replacement of the framework metal ion, the replacement of the framework ligand led to the significant structural reorganization of the framework.
행사명 : 대한화학회 경기지부 추계 심포지엄 행사일자 : 2016년 11월 10일(목) 오후 4시 개최장소 : 성균관대학교 자연과학캠퍼스 화학관 1층 첨단강의실 (330118호) 주최 : 대한화학회 경기지부 발표편수 : 교수 구두발표(3편) 담당자 : 차상원 교수(한국외국어대학교 화학과, email@example.com) 내용- 경기도 지역내 신진 연구자 연구분야 소개 및 학술활동 강화- 경기지부 회원 학문교류 및 친목 도모- 일정 4:00~4:30 등록 4:30~4:35 개회사 및 환영사 – 김연규 지부장 4:35~5:00 이안나 교수 (명지대 화학과) “Organocatalyzed Asymmetric Reactions” 5:00~5:25 강경태 교수 (경희대 응용화학과) “Behaviors of Neurons on Nanotopographies” 5:25~5:50 송창식 교수 (성균관대 화학과) “Sustainable Photoactive Polymer Systems Enabled by Metal-Terpyridine-based Self-Assembly” 5:50~6:00 폐회사 및 기념촬영
============================================================== <세미나1> 제 목 : Modeling of chemical and physical processes: towards a quantitative engineering approach– practical applications 연 사 : Prof. Phillipe Heynderickx(GHENT UNIVERSITY) <세미나2> 제 목 : Defect creation via synthesis procedure in metal-organic frameworks 연 사 : Prof. Francis.Verpoort(GHENT UNIVERSITY) 일 시 : 2016년 10월 26일(수) 오후 2시 30분 장 소 : 화학관 첨단강의실 (330118호실) ============================================================== <세미나1> Modeling of chemical and physical processes: towards a quantitative engineering approach– practical applications In the early days, researchers were relying on performed experiments to describe reality vialaboratory tests. For example in catalysis (blue triangle in given figure), materials were prepared,characterized in a physical way (e.g. XRD, TEM, BET…) or chemical way (selectivereactions). This practice gained power when computational possibilities were created via theuse of a computer. The next step in this natural process of research was to come up with kineticor physical models describing reality as adequate as possible, giving rise to chemical andphysical descriptors of this reality.Today, the research of Prof. Dr. ir. Philippe M. Heynderickx focuses on the green triangle inthe figure: a combination of catalytic testing of materials (MOFs for e.g. selective adsorptionor fine-chemical reactions or metal oxides catalysts for e.g. selective oxidation reactions), thecorresponding kinetic modeling via fundamental reaction steps using intrinsic data and theupscaling to industrial proportion via reactor simulation.The long-term strategy is the development, construction and implementation of intrinsic kineticmodels describing catalytic reactions for daily relevant applications. Especially environmentalapplications in ‘green chemistry’ conversion, environmental sensors, catalysis andenergy storage applications are envisaged. ------------------------------------------------------------------------------------------- <세미나2> Defect creation via synthesis procedure in metal-organic frameworks Francis Verpoort1,2,3,4, 1 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Center for Chemical and Material Engineering, Wuhan University of Technology, Wuhan 430070, P.R. China 2 School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, P.R. China. 3 Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281-S3, 9000, Ghent, Belgium 4Ghent University, Global Campus Songdo, 119 Songdomunhwa-Ro, Yeonsu-Gu, Incheon, Korea *E-mail: Francis@whut.edu.cn / Francis.firstname.lastname@example.org The variation in synthesis procedure, such as solvothermal, room temperature, microwave and spray drying, for metal-organic frameworks (MOFs) effluences the structure, morphology and properties of the MOF materials such as crystal sizes, particle shape, surface area, defect structures (defects) and gas adsorption properties of N2, CO2, CH4 etc. This work describes procedures to synthesize MOFs exposing dramatically different properties compared with the same MOFs prepared in a conventional manner. These results were deduced and supported from crystal morphologies which are related to the rate of crystallization or crystal growth, from surface and porosity properties evaluation from adsorption measurements, and from temperature decomposition analysis. Furthermore, the crystal framework keeps the same structure as proven from the XRD pattern and coordination functional group analysis (Fig.1). The diversity of defect structures correlates with active sites and thus also with the catalytic performance which is confirmed via example of catalytic reactions. The high catalytic performance of MOFs from this invention is related to the presence of more acid and basic sites occurring on defect structure. Knowledge of the nature and amount of defects is of utmost importance to decide which MOF is suitable for a certain catalytic reaction. Fig1. The synthesis ZIF-8 by different procedure (Spray drying: ZIF-8-SP, Microwave: ZIF-8-MW, Room temperature: ZIF-8-RT, Solvothermal: ZIF-8-SV) and their accompanying XRD patterns (a) The crystal morphology, shape and size investigated by SEM technique (b). The crystal morphology evolution with rate of crystallization effluence of procedure in MOFs synthesis from rapid to slowing growth (top to down direction) present the cube shape to rhombic dodecahedron shape (c). S. Chaemchuen, N.A. Kabir, K. Zhou, F. Verpoort, Chem. Soc. Rev. 42, 9304-9332 (2013). Z. Fang, B. Bueken, D.E. De Vos, R.A. Fischer, Angew. Chem. Int. Ed.54, 7234-7254 (2015)
============================================================== 제 목 : Interfaces in Science and Technology 연 사 : Prof.Per Claesson(KTH Royal Institute of Technolog) 일 시 : 2016년 10월 18일(화) 오후 4시 30분 장 소 : 화학관 첨단강의실 (330118호실) ============================================================== Interfaces in Science and Technology Per Claesson, email@example.com KTH Royal Institute of Technology, School of Chemical Science and Engineering, Department of Chemistry, Division of Surface and Corrosion Science, Drottning Kristinas väg 51, SE-100 44 Stockholm, Sweden Abstract Interfaces are becoming key to development in a range of areas, including development of nanomeaterials and nanocomposities, green corrosion protection systems, bisurfaces and biomaterials, anti-icing technologies, and aqueous lubrication technologies. This presentation will provide an overview of some activities at the Surface and Corrosion Science Division at the Royal Institute of Technologyin Stockholm. The presentation will introduce and discuss the following topics: The quest for green corrosion protective coatings, where we have achived promising results with several different systems including i) UV-cured polymer films (≈ 10 µm thick) incorporating small amount of conducting polymer, ii) superhydrophobic coating layers, and iii) thin films (≈ 100 nm) of mussel adhesive polymers and ceria nanoparticles. Nanomechanical properties of the interphase, i.e. the region next to a particle embedded in a polymer matrix. Such studies are performed using scanning probe methods and provide direct measurements of nanomechanical properties with a high spatial resolution. Molecular lubrication synergies underlying the outstanding lubrication properties of synovial joints, and the development of biomimetic lubricants providing low friction and high load bearing capacity in aqueous media, where we have achieved results that are comparable to that found in synovial joints. The surface chemical approach to anti-icing and de-icing surfaces, where modification of surface properties are utilized for achieving low ice adhesion. At present it seems that such approaches could provide benefit for relatively small surfaces as found in heat exchangers and windscreens.
============================================================= 제 목 : Living Supramolecular Polymerization 연 사 : Dr Kazunori Sugiyasu(NIMS) 일 시 : 2016년 10월 6일(목) 오후 4시 30분 장 소 : 화학관 세미나실 (330226호실) ============================================================== Living Supramolecular Polymerization Kazunori Sugiyasu Molecular Design & Function Group, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan E-mail: SUGIYASU.Kazunori@nims.go.jp Supramolecular polymers are a new type of polymer in which monomeric units are brought together by reversible and highly directional non-covalent bonds, such as hydrogen bonding, coordination bonding, and p-p stacking. Therefore, supramolecular polymers are endowed with intriguing functionalities and properties that originate from the dynamic behavior of the non-covalent bonds. However, the “dynamic” reversible polymerization process in turn implies that controlling the length of supramolecular polymers is entropically unlikely. As such, in contrast to conventional polymer chemistry, an important challenge in realizing living polymerization technique has still remained in the supramolecular polymer chemistry1. In this presentation, I would like to show the first example of living supramolecular polymerization reported by us recently2. Our supramolecular polymerization was very unique in that the polymerization pathway was coupled with a competing aggregation pathway3. This pathway complexity dictated the spontaneous supramolecular polymerization to be kinetically controlled, and the addition of “seeds” of the supramolecular polymer initiated the supramolecular polymerization. We have investigated this polymerization process in a similar way to analyze the living polymerization: (1) the polymerization kinetics was the first order to the concentration of the seeds, (2) polymerization can be repeated many times, and (3) polydispersity indices (PDI) of the obtained polymers were around 1.1. All these results demonstrated that we succeeded for the first time in realizing living supramolecular polymerization. Scheme 1. Pathway complexity of supramolecular polymerization2. References (a) de Greef, T. F. A.; Smulders, M. M. J.; Wolffs, M. ; Schenning, A. P. H. J.; Sijbesma, R. P.; Meijer, E. W. Chem. Rev. 2009, 109, 5687; (b) van der Zwaag, D.; de Greef, T. F. A.; Meijer, E. W. Angew. Chem. Int. Ed. 2015, 54, 8334; (c) Ogi, S.; Stepanenko, V.; Sugiyasu, K.; Takeuchi, M.; Würthner, F. J. Am. Chem. Soc. 2015,137, 3300; (d) Kang, J.; Miyajima, D.; Mori, T.; Inoue, Y.; Aida, T. Science2015, 347, 646. Ogi, S.; Sugiyasu, K.; Manna, S.; Samitsu, S.; Takeuchi, M. Nat. Chem. 2014, 6, 188. Ogi, S.; Fukui, T.; Melinda, L. J.; Takeuchi, M.; Sugiyasu, K. Angew. Chem. Int. Ed. 2014, 53, 14363.
제 목 : Control of molecular orientation, thermal stability, and photochemical stability in vapor-deposited organic glasses
연 사 : Mark D. Ediger 교수(University of Wisconsin-Madison)
일 시 : 2016년 9월 29일(목) 오후 4시 15분 장 소 : 화학관 첨단강의실(330118호)
Control of molecular orientation, thermal stability, and photochemical stability in vapor-deposited organic glasses
University of Wisconsin-Madison
We have used physical vapor deposition and the mobility of glassy surfaces to prepare what are likely the most stable glasses on the planet.(1) These materials have the properties expected for “million-year-old” glasses, including high density and high mechanical moduli.(2) Surprisingly, these glasses “melt” like crystals, with a constant velocity transformation front.(3) In addition, they resist photochemical degradation better than liquid-cooled glasses. Molecular orientation in vapordeposited glasses can be highly anisotropic.(4) These properties all depend systematically on the substrate temperature during deposition and can be measured efficiently with high throughput spectroscopic ellipsometry.(5)
The interesting properties of vapor-deposited glasses arise from the high mobility of glass surfaces. During deposition, molecules near the free surface have the opportunity to sample many different packing arrangements. This mechanism allows the molecular orientation in vapor-deposited glasses to be predicted from molecular dynamics computer simulations(4, 6) and could be useful for optimizing the performance of organic light emitting diodes (OLEDs).
1. Swallen SF, et al. (2007) Organic glasses with exceptional thermodynamic and kinetic stability. Science 315(5810):353-356.
2. Kearns KL, Still T, Fytas G, & Ediger MD (2010) High-Modulus Organic Glasses Prepared by Physical Vapor Deposition. Adv. Mater. 22(1):39-+.
3. Swallen SF, Traynor K, McMahon RJ, Ediger MD, & Mates TE (2009) Stable Glass Transformation to Supercooled Liquid via Surface-Initiated Growth Front. Phys. Rev. Lett. 102(6):065503.
4. Dalal SS, Walters DM, Lyubimov I, de Pablo JJ, & Ediger MD (2015) Tunable molecular orientation and elevated thermal stability of vapor-deposited organic semiconductors. P Natl Acad Sci USA 112(14):4227-4232.
5. Dalal SS, Fakhraai Z, & Ediger MD (2013) High-Throughput Ellipsometric Characterization of Vapor-Deposited Indomethacin Glasses. J. Phys. Chem. B 117(49):15415-15425.
6. Singh S, Ediger MD, & de Pablo JJ (2013) Ultrastable glasses from in silico vapour deposition. Nature Materials 12(2):139-144.
===================================================================================== 제 목 : Efficient Synthetic Methods of N-Heterocyclic Compounds using Pyridinium Zwitterion 연 사 : 유은정 교수(강원대학교) 일 시 : 2016년 6월 9일(목) 오후 4시 30분 장 소 : 화학관 세미나실 (330118호실) ===================================================================================== Efficient Synthetic Methods of N-Heterocyclic Compounds using Pyridinium Zwitterion Eun Jeong Yoo Department of Chemistry, Kangwon National University, Chuncheon 200-701, Korea E-mail:firstname.lastname@example.org [m+n]-Dipolar cycloaddition is a powerful and widely used strategy for synthesizing heterocyclic compounds in a single operation without giving rise to byproducts. Among the known dipoles, azomethine ylide, consisting of an iminium ion adjacent to a carbanion, is an allyl anionic type 1,3-dipole that can be applied to construct N-heterocyclic compounds. However, most studies have mainly focused on [3+2]-dipolar cycloaddition using well-known 1,3-dipoles and 2p-dipolarophiles, while scarce attention has been focused on the development of new types of dipoles, such as 1,2-dipole, 1,4-dipole, and 1,5-dipole, for the formation of non-five-memberted heterocycles. In this presentation, [5+n]-dipolar cycloaddition, which is an extraordinary tool for formation of medium-sized N-heterocyclic compound, will be present. Air-stable pyridinium zwitterion is efficiently prepared via the rhodium-catalyzed reaction between pyridines and 1-sulfonyl-1,2,3-triazoles. This unprecedented pyridinium zwitterion are quite stable and exhibits different pattern of charge distribution in comparison with that of typical azomethine ylides. In addition, isolated zwitterions could be used as a 1,5-dipole for forming medium-sized heterocyclic compounds. Thermal [5+2]-dipolar cycloaddition of pyridinium zwitterions and dimethyl acetylenedicarboxylate (DMAD) successfully occurs to afford the seven-membered heterocycles with excellent yields. This breakthrough spurred the development of rhodium(II)-catalyzed three-component [5+2] cycloaddition reactions of pyridines, 1-sulfonyl-1,2,3-triazoles, and activated alkynes via the in situ generated 1,5-dipole; thus, a user-friendly and operationally simple strategy for systematic generation of the core structure of 1,4-diazepines was afforded. We will also discuss a new type of intermolecular rhodium(II)-catalyzed [5+3]-dipolar cycloaddition of pyridinum zwitterions and enol diazoacetates. This higher-order cycloaddition allows for the formation of an eight-membered heterocyclic skeleton, which is otherwise difficult to construct. The optimized dipolar cycloaddition occurs efficiently under mild conditions over a wide range of pyridinium zwitterions with high functional group tolerance. References Lee, D. J.; Ko, D.; Yoo, E. J.* “A Class of Rh(II)-Catalyzed Cycloaddition Reaction of Non-classical 1,5-Dipoles for Formation of Eight-Membered Heterocycles” Angew. Chem., Int. Ed. 2015, 54, 13715. Yoo, E. J.* “Azomethine Ylide: an Isolable 1,5-Dipole for Affecting [5+2] Cycloaddition Reaction” Synlett 2015, 26, 2189 (SYNPACTS, invited article). Lee, D. J.; Han, H. S.; Shin, J.; Yoo, E. J.* “Multicomponent [5+2] Cycloaddition Reaction for the Synthesis of 1,4-Diazepines: Isolation and Reactivity of Azomethine Ylides” J. Am. Chem. Soc. 2014, 136, 11606
2016 Spring/Summer Semester Plenary Seminar at SKKU Department of Chemistry ====================================== 제 목 : In vivo NMR to elucidate Brain Function 연 사 : 김성기 교수(Center for Neuroscience Imaging Research Institute for Basic Science, SKKU) 일 시 : 2016년 6월 2일(목) 오후 4시 15분 장 소 : 화학관 첨단강의실(330118호) -------------------------------------- In vivo NMR to elucidate Brain Function Seong-Gi Kim(email@example.com) Center for Neuroscience Imaging Research Institute for Basic Science Sungkyunkwan University NMR has been extensively used in chemistry for determining molecular structures and dynamics. When NMR is used as an imaging mode with gradient coils, it is referred to as magnetic resonance imaging, which is used for non-invasive diagnostics of diseases. In my research, MRI is used for determining brain function non-invasively by utilizing a change of paramagnetic deoxyhemoglobin. In my talk, I will discuss basic idea of functional MRI, current research lines, and IBS center’s NMR facility.