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제 목 : Better Biosensing Platforms with Metallic and Non-metallic Nanoparticles for Biomedical Applications
연 사 : 이혜진 교수(경북대학교)
일 시 : 2020년 11월 5일(목) 오후 4시 30분
방번호: 170 974 2739
Better Biosensing Platforms with Metallic and Non-metallic Nanoparticles for Biomedical Applications
Hye Jin Lee
Department of Chemistry, Kyungpook National University, Daegu 41566, Korea.
In this talk, I will highlight our recent efforts made on the development of highly sensitive and selective biosensing platforms in conjunction with biofunctionalized nanoparticles for medical diagnosis. The efforts involve a concerted methodology integrating a wide range of metallic and non-metallic nanoparticles conjugated with bio-receptors specific to a target analyte and a new bioaffinity sandwich assay involving a pair of bio-receptors alongside surface site selective enzyme reaction. As an example, the development of different sets of antibody-DNA aptamer bio-receptor pair involved sandwich or enzyme-amplified bioassays specific for target biomarker analytes with surface plasmon resonance, fluorescence microscopy or electrochemical biosensing methods will be discussed. The biomarker analytes chosen which can be potentially used for various disease diagnoses are heterogeneous nuclear ribonucleoprotein A1, tau 381, amyloid-beta(1-42), alpha-1-antitrypsin, as well as noro and avian influenza virus proteins in addition to some of metabolites in biological fluids.1-4 Lastly, future aspects and challenging issues of our biosensing methodologies will be discussed.