Research on theragnostic biomaterials for severe COVID-19

  • POSTED DATE : 2021-09-15
  • WRITER : 화학과
  • HIT : 2996
  • DATE : 2021년 9월 16일(목) 오후 4시 30분
  • PLACE : Webex

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제  목 : Research on theragnostic biomaterials for severe COVID-19
연  사 : 이원화 교수(성균관대학교 화학과)
일  시 : 2021년 9월 16일(목오후 4시 30분


방번호: 170 974 2739



Research on theragnostic biomaterials for severe COVID-19


Wonhwa Lee


Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea




The outbreak of highly contagious and deadly SARS-CoV-2, also known as Coronavirus Disease 2019 (COVID-19) has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a highly reliable theragnostic biomarker, acetylated 676th lysine transforming growth factor beta-induced protein (TGFBIp K676Ac). The TGFBIp K676Ac was consistently elevated in the blood of SARS-CoV-2 pneumonia patients (n=113); especially in patients of intensive care unit (ICU) than non-ICU. Patients’ blood samples showed increased cytokines and lymphopenia, which are exemplary evidence of SARS-CoV-2 pneumonia. Treatment of TGFBIp neutralizing antibodies suppressed the cytokine storm. The increased level of TGFBIp K676 Ac in ICU patients implies that it can be used as a reliable theragnostic biomarker for SARS-CoV-2.                                               



1. Jong-Sup Bae, Wonhwa Lee, Ju-Ock Nam, Jung-Eun Kim, Shin-Woo Kim, In-San Kim. Transforming Growth Factor β-induced Protein Promotes Severe Vascular Inflammatory Responses. (2014), American Journal of Respiratory and Critical Care Medicine, 189(7), 779-786.

2. Jong-Sup Bae, Wonhwa Lee, Hye-Nam Son, You-Mie Lee, In-San Kim Anti-TGFBIp antibody ameliorates vascular barrier dysfunction and improves survival in sepsis (2014), Acta Physiologica, 212 (4), 306-315.

3. Wonhwa Lee, Eun Ji Park, Oh Kwang Kwon, Hyelim Kim, Youngbum Yoo, Shin-Woo Kim, Young-Kyo Seo, In-San Kim, Dong Hee Na, Jong-Sup Bae. Dual peptide-dendrimer conjugate inhibits acetylation of transforming growth factor β-induced protein and improves survival in sepsis (2020), Biomaterials, 246, 120000.

4. Hee Ho Park, Hong Nam Kim, Hyelim Kim, Youngbum Yoo, Hyosoo Shin, Eun Young Choi, Jong-Sup Bae, Wonhwa Lee. Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia (2020) Science Advances, 6(31), eabc1564.



Severe COVID-19, Theragnostics, TGFBIp, Cytokine storm