세미나가 이번주 목요일(9월 16일) 오후 4시 30분에 개최됩니다.
많은 참여 부탁드립니다.
제 목 : Research on theragnostic biomaterials for severe COVID-19
연 사 : 이원화 교수(성균관대학교 화학과)
일 시 : 2021년 9월 16일(목) 오후 4시 30분
방번호: 170 974 2739
Research on theragnostic biomaterials for severe COVID-19
Department of Chemistry, Sungkyunkwan University, Suwon 16419, Korea
The outbreak of highly contagious and deadly SARS-CoV-2, also known as Coronavirus Disease 2019 (COVID-19) has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a highly reliable theragnostic biomarker, acetylated 676th lysine transforming growth factor beta-induced protein (TGFBIp K676Ac). The TGFBIp K676Ac was consistently elevated in the blood of SARS-CoV-2 pneumonia patients (n=113); especially in patients of intensive care unit (ICU) than non-ICU. Patients’ blood samples showed increased cytokines and lymphopenia, which are exemplary evidence of SARS-CoV-2 pneumonia. Treatment of TGFBIp neutralizing antibodies suppressed the cytokine storm. The increased level of TGFBIp K676 Ac in ICU patients implies that it can be used as a reliable theragnostic biomarker for SARS-CoV-2.
1. Jong-Sup Bae, Wonhwa Lee, Ju-Ock Nam, Jung-Eun Kim, Shin-Woo Kim, In-San Kim. Transforming Growth Factor β-induced Protein Promotes Severe Vascular Inflammatory Responses. (2014), American Journal of Respiratory and Critical Care Medicine, 189(7), 779-786.
2. Jong-Sup Bae, Wonhwa Lee, Hye-Nam Son, You-Mie Lee, In-San Kim Anti-TGFBIp antibody ameliorates vascular barrier dysfunction and improves survival in sepsis (2014), Acta Physiologica, 212 (4), 306-315.
3. Wonhwa Lee, Eun Ji Park, Oh Kwang Kwon, Hyelim Kim, Youngbum Yoo, Shin-Woo Kim, Young-Kyo Seo, In-San Kim, Dong Hee Na, Jong-Sup Bae. Dual peptide-dendrimer conjugate inhibits acetylation of transforming growth factor β-induced protein and improves survival in sepsis (2020), Biomaterials, 246, 120000.
4. Hee Ho Park, Hong Nam Kim, Hyelim Kim, Youngbum Yoo, Hyosoo Shin, Eun Young Choi, Jong-Sup Bae, Wonhwa Lee. Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia (2020) Science Advances, 6(31), eabc1564.
Severe COVID-19, Theragnostics, TGFBIp, Cytokine storm