세미나가 다음주 목요일(10월 6일) 오후 4시 30분에 개최됩니다.
많은 참여 부탁드립니다.
* 온/오프라인 세미나로 진행됩니다.
제 목 : Neutrophil Dysfunction in Pulmonary Post-Acute Sequelae of SARS CoV-2 infection (PASC)
연 사 : 박주원 교수(하와이 대학교)
일 시 : 2022년 10월 6일(목) 오후 4시 30분
Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in nearly one third of individuals patients have residual symptoms, so called Post-Acute Sequelae of SARS-CoV-2 infection (PASC). Neutrophils have a critical role of host defense against infection, but uncontrolled or inappropriate neutrophil responses can contribute to immunopathology in infection, inflammatory diseases, and acute respiratory distress syndrome related to COVID-19. Literature to date demonstrates compelling evidence of increased neutrophils counts and neutrophil extracellular traps (NETs) formation, a type of neutrophils’ defense mechanism in the circulation and lungs of COVID-19 patients. Excessive NET formation has the potential to initiate and propagate inflammation and microthrombosis supporting the hypothesis that NETs induce organ damages during COVID19 infection that linked to develop prolonged symptoms. In this seminar, I will share the current knowledge on neutrophils and COVID-19 pathogenesis with a particular emphasis on NET. Also, I will introduce my current research project investigating phenotypic alteration of low-density granulocyte, a subset of neutrophils within peripheral blood mononuclear cells (PBMC) fraction in individuals up to fourteen months after COVID-19 infection, alongside comparator groups, with and without, residual pulmonary symptoms.