Seminar

Seminar

[세미나 공지] - 2014년 9월 26일(금)

  • POSTED DATE : 2014-09-23
  • WRITER : 관리자
  • HIT : 2629
  • DATE : 2014-09-26
  • PLACE : 화학관1층 330126호실

이번주 금요일(9월 26일)에 세미나가 개최됩니다.

많은 참석 부탁드립니다.
감사합니다.

 

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제  목 :  Process Development of PI3Kβ-Sparing Inhibitor GDC-0032(Taselisib)


연  사 : TRAVIS P. REMARCHUK, PH.D.(Genentech Inc, Small Molecule Process Chemistry)
 

일  시 : 2014년 9월 26일 (금) 오후 4시 30분


장  소 : 화학관 1층 첨단강의실 (330126호실)

 

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 Process Development of PI3Kβ-Sparing Inhibitor GDC-0032(Taselisib)


Genentech Inc, Small Molecule Process Chemistry
1 DNA Way, South San Francisco, CA 94080, USA


  Abstract: GDC-0032 is an orally dministrated potent PI3K kinase inhibitor that was discovered at Genentech and currently in PhI clinical trials for the treatment of cancer. In this presentation, the evolution of the process chemistry from the medicinal chemistry route up to the current manufacturing route used to produce GDC-0032 on multikilogram scale will be discussed. Multiple routes to the key starting materials as well as a more efficient convergent end-game synthesis to the API will be highlighted.


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