Seminar

Seminar

Investigation of Innovative Synthetic Approach for Successful Implementation of Fragment-Based Design

  • POSTED DATE : 2017-06-02
  • WRITER : 관리자
  • HIT : 3587
  • DATE : 2017-06-07
  • PLACE : 화학관 330118호

=====================================================================================

제  목 : Investigation of Innovative Synthetic Approach for Successful Implementation of Fragment-Based Design


연  사 : 홍승우 교수님(KAIST)


일  시 : 2017년 6월 7일(수) 오전 11시


장  소 : 화학관 1층 첨단강의실 (330118호실)

=====================================================================================


        



Investigation of Innovative Synthetic Approach


for Successful Implementation of Fragment-Based Design


 


Sungwoo Hong


Center for Catalytic Hydrocarbon Functionalizations &


 Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Korea


e-mail: hongorg@kaist.ac.kr


 


Solutions to problems that are posed by organic, medicinal, biological and material science, demand synthetic innovation with efficient synthetic routes. Our current research is focused on studying breakthrough knowledge in catalytic synthetic methods and molecular design that have high impact on broader scientific fields. The state-of-the-art of approach can be seen using systematic experimental and theoretical methods from three steps: (1) development of innovative synthetic methods that allow rapid access to molecular complexity and structural diversity of privileged fragments, (2) fragment-based drug design (FBDD) and de novo design methods connecting privileged building blocks, (3) development of potent and selective inhibitors based on understanding the mechanisms at the molecular level.


The selective C–H bond functionalization has become the favored reaction methods in practical synthetic processes. The new catalytic synthetic methods allow us to perform the unprecedented disconnection of target molecules, affording innovative and imaginative synthetic strategies of so-called “privileged scaffolds”. The power and efficiency of direct C–H functionalization could be further enhanced by combining such catalytic transformations into a one-pot process, which is highly desirable by providing a powerful platform for constructing complicated key motifs from simple starting materials. Subsequent medicinal chemistry studies involving a modular approach and privileged fragments assembly, will provide bases for the development of pharmaceutical agents via structure-based design. The new catalytic synthetic methods will function as competent tools directly utilized in cross coupling reactions capable of connecting privileged building blocks, providing opportunities for the successful implementation of fragment-based drug design (FBDD) and eventually streamline drug discovery research.