제 목 : Chemical Synthesis and Catalysis Harnessing Organosilanes
연 사 : 전준하 교수(Department of Chemistry & Biochemistry University of Texas Arlington)
일 시 : 2019년 8월 7일(수) 오후 4시
장 소 : 화학관 2층 서병인강의실 (330226호실)
Chemical Synthesis and Catalysis Harnessing Organosilanes
Department of Chemistry and Biochemistry The University of Texas at Arlington
Arlington, Texas 76019 E-mail: firstname.lastname@example.org
Environmentally benign, stable, and abundant organosilanes are increasingly utilized in an impressively wide range of synthetic applications involving biomedically relevant agents, catalysts, and drug delivery vehicles. Despite the advances on organosilane chemistry, much less success has been achieved on broadly applicable, highly regio-, stereo-, and chemoselective silylation of unactivated C–C and C–H bonds. The goals of our research research program are to develop highly efficient synthetic methods for preparation of high-value synthetic building blocks and bioactive molecules and to advance our understanding of the associated catalytic mechanisms. Success in these endeavors will accelerate the use of a variety of novel small molecules to be employed in drug discovery and development, thus contributing to the promotion of human health. In this talk, our efforts toward expanding the dimension of organosilicon chemistry directed toward chemical synthesis and catalysis will be presented. Specifically, the progress on design and application of redox neutral and oxidative C–C and C–H silylation methodologies harnessing a traceless hydrosilyl acetal and our new discovery on catalytic hydrogen atom transfer from hydrosilanes to vinylarenes for hydrosilylation and polymerization will be discussed.