세미나가 다음주 목요일(11월 5일)에 개최됩니다.많은 참석 부탁드립니다.감사합니다.===============================================================================제 목 : Better Biosensing Platforms with Metallic and Non-metallic Nanoparticles for Biomedical Applications연 사 : 이혜진 교수(경북대학교)일 시 : 2020년 11월 5일(목) 오후 4시 30분<Webex참여>방번호: 170 974 2739Better Biosensing Platforms with Metallic and Non-metallic Nanoparticles for Biomedical ApplicationsHye Jin LeeDepartment of Chemistry, Kyungpook National University, Daegu 41566, Korea.E-mail: email@example.comIn this talk, I will highlight our recent efforts made on the development of highly sensitive and selective biosensing platforms in conjunction with biofunctionalized nanoparticles for medical diagnosis. The efforts involve a concerted methodology integrating a wide range of metallic and non-metallic nanoparticles conjugated with bio-receptors specific to a target analyte and a new bioaffinity sandwich assay involving a pair of bio-receptors alongside surface site selective enzyme reaction. As an example, the development of different sets of antibody-DNA aptamer bio-receptor pair involved sandwich or enzyme-amplified bioassays specific for target biomarker analytes with surface plasmon resonance, fluorescence microscopy or electrochemical biosensing methods will be discussed. The biomarker analytes chosen which can be potentially used for various disease diagnoses are heterogeneous nuclear ribonucleoprotein A1, tau 381, amyloid-beta(1-42), alpha-1-antitrypsin, as well as noro and avian influenza virus proteins in addition to some of metabolites in biological fluids.1-4 Lastly, future aspects and challenging issues of our biosensing methodologies will be discussed. ================================================================================
세미나가 다음주 월요일(10월 19일)에 개최됩니다.많은 참석 부탁드립니다.감사합니다.===============================================================================제 목 : Ionoelastomer Junctions Between Polymer Networks of Fixed Anions and Cations연 사 : 김형준 박사(KAIST)일 시 : 2020년 10월 19일(목) 오후 4시 30분================================================================================<Webex 참여안내>-미팅룸 번호 : 570 196 973Ionoelastomer Junctions Between Polymer Networks of Fixed Anions and CationsHyeong Jun Kim, Zhigang Suo, Ryan C. HaywardSoft solids capable of conducting ions offer promise for the design of entirely new classes of highly deformable and bio-inspired devices. While resistive and capacitive ionic circuit elements are well established, next generation ionotronics will require advanced elements that can control and switch ion flow. Here, we introduce ‘ionoelastomers’—soft polymer networks capable of selectively conducting either anions or cations—to demonstrate liquid-free, elastic, and stretchable ionic diodes and transistors that operate entirely via non-Faradaic processes. We show that the junction of two oppositely charged ionoelastomers yields an ‘ionic double layer’, analogous to the depletion layer in a semiconducting p-n junction. This enables the design of ionic devices for rectifying and switching non-Faradaic ionic currents. Further, soft and stretchable ionoelastomer junctions provide fundamentally new functionalities including: 1) low voltage reversible electro-adhesion and 2) electro-mechanical transduction, i.e., the conversion of mechanical deformation into electrical signals. Our studies provide new fundamental insight on the interface between two oppositely charged ionoelastomers and open opportunities for the application of these soft ion-conducting devices.
세미나가 이번주 목요일(10월 15일)에 개최됩니다.많은 참석 부탁드립니다.감사합니다.===============================================================================제 목 : High-affinity and controllable host-guest chemistry as a new supramolecular tool for biology and biomedicine연 사 : 박경민 박사(IBS)일 시 : 2020년 10월 15일(목) 오후 4시 30분================================================================================<Webex 참여안내>-미팅룸 번호 : 571 508 642High-affinity and controllable host-guest chemistry as a new supramolecular tool for biology and biomedicineKyeng Min ParkCenter for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS),Pohang 37673, Republic of KoreaDue to a high binding affinity (Ka ~ 1013 M-1), the streptavidin (Sv) and biotin (BT) as a protein-ligand binding pair has been utilized as a useful tool for various bioapplications including protein imaging and identification. However, the Sv-BT pair has some intrinsic shortcomings; 1) interference of binding from endogenous biotins, 2) false positive signals caused by endogenously biotinylated proteins 3) difficulty in chemical modification and instability of streptavidin (protein) degraded by proteases in cellular conditions. Recently, we developed a new ultrastable and controllable synthetic binding pair as “supramolecular latching system” consisting of a pumpkin-shaped synthetic host molecule, cucurbituril (CB) and adamantylamine (AdA), which has almost comparable (or even higher) binding affinity (Ka ~1012-15 M-1) to Sv-BT with unique features including 1) bio-orthogonality in binding which does not affected by endogenous biomolecules such as biotin, 2) small size with stable and robust chemical structure, 3) scalability using known chemical synthetic methods and 4) controllable binding affinity by treating strong competitors. In this talk, I will introduce our recent efforts to develop this supramolecular latching system as a new molecular tool for various bioapplications (Fig. 1) including visualization and identification of spatial proteins in cells and cost-effective purification of therapeutic proteins in high purity. In addition, future direction of research and development of this new molecular tool will be discussed. Figure 1. Schematic illustration of “supramolecular latching system” and its bioapplicationsReferences1. An, J.; Kim, S.; Shrinidhi, A.; Kim, J.; Banna, H.; Sung, G.; Park, K. M.* M.*; Kim, K* “Purification of proteintherapeutics via high aff inity supramolecular host guest interactions” Nat. Biomed. Eng. 2020 , in press.(DOI:10.1038/s41551 020 0589 7).2. Ghosh; S. K.; Dhamija, A.; Ko, Y. H.; An, J.; Hur, M. Y.; Boraste, D. R.; Seo, J.; Lee, E.*; Park, K. M.*Kim, K.* Superacid mediated functio nalization of hydroxylated cucurbit[ n ]urils J. Am. Chem. Soc. 2019 ,141, 17503.3. Kim, K. L.; Sung, G..; Sim, J.; Murray, J.; Li, M.; Lee, A.; Shrinidhi, A.; Park, K. M. M.*; Kim, K.*“Supramolecular latching system based on ultrastable synthetic binding pair s as versatile tools for proteinimaging” Nat. Commun. 2018 , 9, 1712.4. Li, M.; Lee, A.; Kim, K. L.; Murray, J.; Shrnidhi, A.; Sung, G.; Park, K. M. M.*; Kim, K.* “Autophagy caughtin the act: a supramolecular FRET Pair based on an ultrastable synthetic Host g uest complex visualizesautophagosome lysosome fusion.” Angew. Chem. Int. Ed. 2018, 57 ,5. Park, K. M. M.*; Baek, K.; Ko, Y. H.; Shrinidhi, A.; Murray; Jang, W. H.; Kim, K. H.; Lee, S., Yoo, J.; Kim,S.; Kim, K.* “Mono allyloxylated cucurbituril acts as an unconventional amphiphile to formlight responsive vesicles” Angew. Chem. Int. Ed. 2018 , 57, 3132
세미나가 이번주 화요일(10월 13일)에 개최됩니다.온라인으로 진행되는 세미나로, 많은 참여 부탁드립니다.감사합니다.===============================================================================제 목 : Multifunctional Inorganic Nanoparticles for Modulation of Hypoxic Microenvironments 연 사 : 이노현 교수(국민대학교)일 시 : 2020년 10월 13일(화) 오후 4시 30분<WebEx참여>방번호: 170 400 9240링크: https://skku-ict.webex.com/meet/sson ========================================================================Multifunctional Inorganic Nanoparticles for Modulation of Hypoxic Microenvironments 이노현국민대학교 신소재공학부(firstname.lastname@example.org*) Due to their unique physicochemical properties, inorganic nanoparticles (NPs) have emerged as novel imaging, diagnostic, and therapeutic agents for the future biomedical field. In particular, hypoxic inflammatory microenvironments, which is often found at disease sites in the body, can be easily controlled using NPs with various combinations. Catalytic NPs continuously generate oxygen using intracellular hydrogen peroxide in the hypoxic microenvironment. They can also control the phenotype of macrophages in the inflammatory microenvironment, alleviating the inflammation. Moreover, immune cell can be targeted using the NPs functionalized with targeting moieties, enabling the delivery of the functional NPs to inflammatory microenvironments. I would like to describe the applications of multifunctional inorganic NPs for modulation of hypoxic and inflammatory microenvironments.Firstly, biocompatible manganese ferrite NP-anchored mesoporous silica NPs (MFMSNs) were designed to overcome hypoxia, consequently enhancing the therapeutic efficiency of photodynamic therapy (PDT). By exploiting the continuous oxygen-evolving property of manganese ferrite NPs through the Fenton reaction, MFMSNs relieved hypoxic condition using a small amount of NPs and improved therapeutic outcomes of PDT for tumors in vivo. Secondly, manganese ferrite and ceria NP-anchored mesoporous silica NPs (MFC-MSNs) that can synergistically scavenge reactive oxygen species (ROS) and produce oxygen for M1 macrophage reduction and M2 macrophage induction for rheumatoid arthritis (RA) treatment. MFC-MSNs exhibited a synergistic effect on O2 generation attributed to hydroxyl complementary reaction of ceria NPs scavenging the intermediate hydroxyl radical generated by manganese ferrite NPs during the Fenton reaction, leading to efficient polarization of M1 to M2 macrophages. Intra-articular administration of MFC-MSNs to RA-suffering rats alleviated hypoxia, inflammation, and pathological features in the joint.Lastly, we developed a click reaction-assisted immune cell targeting (CRAIT) strategy to delivery drug-loaded nanoparticles deep into the avascular regions of the tumor. Immune cell-targeting CD11b antibodies were modified with trans-cyclooctene to enable bioorthogonal click chemistry with mesoporous silica nanoparticles functionalized with tetrazines (MSNs-Tz). Sequential injection of modified antibodies and MSNs-Tz at intervals of 24 h resulted in targeted conjugation of the nanoparticles onto CD11b+ myeloid cells, which served as active vectors into tumor interiors. The CRAIT strategy allows the deep tumor penetration of drug-loaded nanoparticles, resulting in enhanced therapeutic efficacy in an orthotopic 4T1 breast tumor model.
세미나가 이번주 화요일(10월 6일)에 개최됩니다.온라인으로 진행되는 세미나로, 많은 참여 부탁드립니다.감사합니다.=======================================================================제 목 : Molecular designing in carbon-based nanomaterials and their catalytic and optical applications연 사 : 박성진 교수(인하대학교)일 시 : 2020년 10월 6일(화) 오후 4시 30분<Webex참여>방번호: 573 338 453링크: https://skku-ict.webex.com/meet/songcs======================================================================== Molecular designing in carbon-based nanomaterials and their catalytic and optical applications Sungjin Park* 1Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, Korea(*email@example.com) The generation of molecularly dispersed active species on the surface of carbon-based network enables to utilize advantages of molecular catalysts as well as to extremely expose active species without aggregation at the surface. In the first part of this presentation, I will discuss my recent research activities on this concept. Novel hybrids were generated by the reaction of Co-containing organometallic molecules and carbon-based materials. Three dimensional (3D) carbon nitrides (C3N4), which are also referred to as graphitic or polymeric C3N4, have attracted intense research interest because of their visible-light active, fluorescent, biocompatible, and catalytically active properties. In the second part of this presentation, the use of carbon nitride-based materials as photocatalysts and light-emitting materials will be discussed.
<K-BioX 글로벌 프로젝트>1. K-BioX (Non-Profit Organization) 와 한국 11개 대학이 공동 주최 하는 Global K-BioX 세미나 이 첫 번째 강연을 소개합니다^^2. 9월 15일 화요일 오전 10시 세미나 (웨비나)3. 발표자 : 도신호 교수 (Harvard Medical School) http://www.kbiox.org/ ( 연사 소개 동영상) in K-BioX 홈페이지4. 발표 주제 : Secret guide to the forefront of Healthcare AI 5. 패널연사 : 김병학 박사 (실리콘밸리 AI 스타트업), 김용수 교수 (네델란드 암센터) 6. Host: 성대 성균융합원 (주경민 부원장) : < 성균융합원 소개 : 주경민 부원장 >7. 사회자: 정명진 교수(삼성서울병원, AI연구센터 센터장> 8. 행사 주관 : K-BioX (Non-Profit Organization)
* 본 세미나 참석대상은 화학과교수님으로 제한합니다.안녕하세요. 박혜원 조교입니다. 세미나가 다음주 금요일(2월 14일)에 개최됩니다.많은 참석 부탁드립니다.감사합니다.===============================================================================제 목 : Open Innovation: fighting against/with Googling 연 사 : 장지환 박사님((주)유케어트론 대표/신소재공학부 산학교수)일 시 : 2020년 2월 14일(금) 오후 2시장 소 : 화학관 2층 서병인강의실 (330226호실)================================================================================
세미나가 이번주 목요일(2월 6일)에 개최됩니다.많은 참석 부탁드립니다.감사합니다.===============================================================================제 목 : Ordered Mesoporous Carbon Nitrides and their Multiple Applications연 사 : Prof. Ajayan Vinu(University of Newcastle)일 시 : 2020년 2월 6일(목) 오전 11시장 소 : 화학관 1층 조규학강의실 (330126호실)================================================================================ Ordered Mesoporous Carbon Nitrides and their Multiple Applications Ajayan Vinu Global Innovative Center for Advanced Nanomaterials, University of Newcastle, Australia, Ajayan.firstname.lastname@example.org;Mesoporous carbon nitrides (MCN) with large surface areas and uniform pore diameters are unique semiconducting materials and exhibit highly versatile structural and excellent physicochemical properties which find them applications in diverse fields such as metal free catalysis, photocatalytic water splitting, energy storage and conversion, gas adsorption, separation, and even sensing. Although there have been series of mesoporous boron nitride or carbon nitride materials with C3N4 stoichiometry reported [1-6], only a little attention has been given to the mesoporous materials with C3N5, C3N6, C3N7, etc even though they have unique band structure. In this talk, I will present the preparation, structural and morphological control, and the functionalization of highly ordered and graphitic carbon nitride materials with tunable nitrogen contents. The relation between the structural parameters and the performance of these materials in various applications including catalysis, sensing, and carbon capture and energy storage will be demonstrated [7-11]. In the second part of the talk, the fabrication of various nanoporous films including carbons, nitrides, semiconducting nanostructures, and biomolecules with tunable macroporosity, thickness, and morphology will be presented . These porous films have been fabricated by using P123 block copolymer and polystyrene spheres as templates, and utilized for sensing. For example, nanoporous CN film offers the superior affinities for toxic acid molecules but the selectivity can be totally reversed for basic molecule after treatment with UV. The application of these fascinating materials for carbon capture, water splitting, oxygen reduction reaction will also be presented [12-17].ReferencesVinu et al., Chem. Soc. Rev. 2017, 46, 72. A. Vinu, Adv. Func. Mater. 2008, 18, 816. Vinu et al., Angew. Chemie International Edition, 2015, 127, 8527-8530.Vinu et al., Angew. Chemie International Edition, 2009, 48, 7884.K. Ariga, A. Vinu, M. Miyahara, J.P. Hill, T. Mori, J. Am. Chem. Soc. 2007, 129, 11022.Vinu et al. Angew. Chemie International Edition, 2008, 47, 7254.Vinu et al., Angew. Chemie International Edition, 2010, 49, 9737-9739. Vinu et al., Angew. Chemie International Edition, 2009, 48, 7358.Vinu et al., Angew. Chemie International Edition, 2010, 49, 5961-5965. Vinu et al., Angew. Chemie International Edition, 2012, 51, 2859. Vinu et al., Chem. Commun. 2014, 50, 5976.Vinu et al., Angew. Chemie International Edition, 2017, 56, 8481.Vinu et al., Angew. Chemie International Edition, 2018, 57, 569.Vinu et al. Adv. Mater., 2017, 29, 1702295. Vinu et al. Chem. Soc. Rev. 2018, 47, 2680-2721. Vinu et al. Angew. Chemie International Edition, 2018, 130, 17381. Vinu et al. Advanced Materials, 2019, in press