세미나가 이번주 수요일(11월 24일) 오후 4시 30분에 개최됩니다.
많은 참여 부탁드립니다.
===============================================================================
제  목 : Harnessing reversibility in catalytic carbonylation and halogenation reactions
연  사 : 이용호 교수(고려대학교)
일  시 : 2021년 11월 24일(수) 오후 4시 30분

<Webex참여>
방번호: 170 762 9924
링크: https://skku-ict.webex.com/meet/chem2
================================================================================

Harnessing reversibility in catalytic carbonylation and halogenation reactions



Yong Ho Lee

Department of Chemistry, Korea University, Seoul, South Korea

Email: yholee@korea.ac.kr



The ability of chemists to harness and control reversible reactions provides a powerful tool in synthesis, as illustrated by the impact of the transfer of molecular hydrogen and alkene metathesis. However, the extension of this strategy to other types of molecules or chemical bonds remains elusive, despite its significant potential to streamline synthesis and chemical processes. Recently, transition-metal catalyzed isofunctional reactions, such as functional group transfer by shuttle catalysis and metathesis, are reinvigorating this approach as a tool for providing flexible and safer target-oriented synthesis.1 This presentation will describe the development of a functional group metathesis process, enabling two distinct transformations, a chlorocarbonylation, and a decarbonylative iodination, by functional group interconversion of two essential classes of electrophiles, aryl iodide and aryl acid chloride.2 Taking advantage of the reversible formation of C(sp2)–I and C(sp2)–COCl bonds and given the synthetic importance of creating new C–C bonds to rapidly increase molecular complexity, this talk will also present the development of several unique carbofunctionalization reactions of unsaturated hydrocarbons, highlighted by versatile and modular CO-free carbonylations3,4 and atom economic halogenations.5

external_image

References

[1] Bhawal, B. N.; Morandi, B. Angew. Chem. Int. Ed.2019, 58, 10074.

[2] Lee, Y. H.; Morandi, B. Nat. Chem.2018, 10, 1016.

[3] Lee, Y. H.; Denton, E. H.; Morandi, B. Nat. Chem.2021, 13, 123.

[4] Lee, Y. H.; Denton, E. H.; Morandi, B. J. Am. Chem. Soc.2020, 142, 20948.

[5] Lee, Y. H.; Morandi, B. Angew. Chem. Int. Ed.2019, 58, 6444.