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제 목 : Chiral Tetrahydrothiophene Ligands in Asymmetric Catalysis
연 사 : Prof. Rong-Jie Chein(Institute of Chemistry, Academia Sinica)
일 시 : 2017년 4월 4일(화) 오후 4시 30분
장 소 : 화학관 1층 강의실 (330118호실)
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Chiral Tetrahydrothiophene Ligands in Asymmetric
Catalysis
Rong-Jie Chein
Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan
E-mail: rjchein@chem.sinica.edu.tw
Chiral sulfur ligands are becoming a versatile tool in organic chemistry due to the
blossomed development achieved in the past years. This presentation describes an
expeditious and efficient preparation of enantiopure (thiolan-2-yl)diarylmethanols and
the applications of their derivatives to catalytic and asymmetric Corey-Chaykovsky
epoxidation,1 the imino Corey-Chaykovsky aziridination,2,3 as well as the first
oxathiaborenium catalyzed asymmetric Diels-Alder reaction.4,5
Figure 1. Synthesis and applications of chiral THT ligands
Reference
1. Wu, H.-Y.; Chang, C.-W.; Chein, R.-J. J. Org. Chem. 2013, 78, 5788-5793.
2. Huang, M.-T.; H.-Y. Wu; Chein, R.-J. Chem. Commun. 2014, 50, 1101-1103.
3. Wang, S.-H.; Chein, R.-J. Tetrahedron, 2016, 72, 2607-2615..
4. Kumar, S. N.; Yu, I. F.; Chein, R.-J. Org. Lett. 2017, 19, 22-25. (Highlighted by
C&EN 2017, 95(1), 9).
5. Tsai, M.-L.; Chein, R.-J. to be submitted.
Rong-Jie Chein (陳榮傑), National Chiao Tung University (Ph.D., 2005), Harvard
University (Postdoctoral Fellow, E. J. Corey Lab, Jan. 2007 - June 2009). Assistant
Research Fellow of Academia Sinica (July 2009 - May 2015). Associate Research
Fellow (May 2015 - ). Research fields: (1) Development of new synthetic strategies
and methods. (2) Total synthesis and the study of the chemistry and biology of natural
products and designed molecules.